acute myocardial infarction is the most important reason of mortality in iran. more than half of these deaths occur without the patient even reaching to a hospital. there is the evidence that patients with better knowledge of the symptoms of mi will seek help earlier. the purpose of this study is to determine how well a predictive model will perform based solely upon patient-reportable clinical...

Using a derivation data set of 1253 patients, we built several logistic regression and neural network models to estimate the likelihood of myocardial infarction based upon patient-reportable clinical history factors only. The best performing logistic regression model and neural network model had C-indices of 0.8444 and 0.8503, respectively, when validated on an independent data set of 500 patie...

Editor—We were interested to read the article of Professor Mahajan and concur with his view that safety can be improved by learning from incidents and near misses. 1 Furthermore , we agree that investigation of incidents should not underestimate the potential of analysing incidents that are near misses or which have not led to patient harm. 1 We also accept that under-reporting of incidents by ...

Whole exome sequencing (WES) is increasingly being used for diagnosis without adequate information on predictive characteristics of reportable variants typically found on any given individual and correlation with clinical phenotype. In this study, we performed WES on 89 deceased individuals (mean age at death 74 years, range 28-93) from the Mayo Clinic Biobank. Significant clinical diagnoses we...

REPORTING INFORMATION • Class B: Report by the close of the next business day after the case or suspected case presents and/or a positive laboratory result to the local public health department where the patient resides. If patient residence is unknown, report to the local public health department in which the reporting health care provider or laboratory is located. • Reporting Form(s) and/or M...

Whole-exome sequencing (WES) arises as a new approach in diagnosing individuals affected by multigenic and complex phenotypes. Herein, we aim to examine whether WES is useful in screening asymptomatic individuals for actionable interventions, which has not yet been established. Twenty-five healthy adults underwent WES, bioinformatics, and manual curation of their exomes. Six participants (24%) ...